Karolinska Institutet Open Archive
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DNA tools for imaging and manipulation of biological samples
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-26)Spatial organization within biological systems is important for understanding mechanisms underlying health and disease. This thesis investigates the role of spatial distribution at cellular and molecular levels, utilizing ... -
Multiple sclerosis, viruses, and B cell depleting therapy : a meeting at the immune system
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-04-25)Multiple sclerosis (MS) is a highly heterogeneous disease with a complex and undiscovered etiology. Two of the strongest established risk factors for developing MS are carriage of the HLA-DRB1*15:01 allele and Epstein-Barr ... -
The motives and ethical justifiability of treating patients with borderline personality disorder under compulsory care
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2024-04-25)This thesis aims to investigate what motives psychiatrists have for detaining patients with BPD under compulsory care. Also, to examine hospital staff’s experiences of treating patients with BPD under involuntary care and ... -
High-capacity in vitro models for the assessment of pain-related mechanisms
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-04-25)Chronic pain affects one in five people. Yet, new efficient drugs with fewer adverse effects remain an unmet need for chronic pain. In vitro models that closer recapitulate relevant disease mechanisms are suggested as a ... -
Health consequences of gender-based harassment at work
(Institutet för miljömedicin / Institute of Environmental Medicine, 2024-04-25)Background: Experiences at work with gender-based violence and harassment (GBVH) from superiors, co-workers or third parties are common. This includes a range of verbal or physical behaviors that can be of a sexual nature ...